Selected outcome studies of cryotherapy for the treatment of cervical dysplasia from the English language literature.

 
Study
Gas
Method
N
F/U (Yrs)
F/U Test*
Cure Rates per Grade (%)
CIN1
CIN2
CIN3
CIS
Total
Townsend 25
NO2
Single
100
1
P
100
95
90
***
93
Schantz 26
NO2
Single
61
2.25
P
95.7
76.3
***
***
83.6
Benedet 18
NO2
Single
843
1
P
95.1
95.7
94.5
92.4
94.3
Benedet 18
NO2
Single
843
5
P
88.2
89.8
91
88
89.4
Benedet 18
NO2
Single
843
10
P
100
86.4
90.9
81.4
85.4
Benedet 27
NO2
Single
516
1.5
P
95
90
87
86
88
Bryson 8
NO2
Double
422
1-4
P
***
***
93
***
***
Draeby 13
NO2
Double
96
10
P
***
92
90.1
***
90.6
Anderson 14
NO2
Double
261
>5
P
94.4
87.5
74.7
***
83.5
Hemming-sson 28
NO2
Double
170
5-8
P
***
***
***
82
84
Schantz 26
NO2
Double
81
2.25
P
97.1
91.3
***
***
93.8
Elmfors 29
NO2
Double
91
0.5-6
P,C
***
97
89
76
86
VanLent 30
NO2
Double
102
1-4
P
***
***
93
***
***
Mitchel 31
NO2
Double
107
2
P, C
***
***
***
***
76
Walton 32
NO2
Both
152
.5-3
P
***
75.8
69.4
***
***
Gray 33
NO2
Both
66
.25-1
P
84
67.7
80
***
75.8
Popkin 34
NO2
Both
208
2.5
P, C
100
95
96
91
91.5
Creaseman 1
NO2,CO2
Double
770
2
P
94.6
92.8
82.2
***
89.8
Tavaheri 35
NO2,CO2
Double
315
1-5
P
95.9
93.3
83.8
84.6
90
Charles 36
NO2,CO2
Double
160
.5-6
P
81.8
83
82.4
80
88.7
Hatch 37
Fr,CO2
Both
696
1
P,C
***
91.5
81.6
***
88.9
Kaufman38
Fr,NO2
Both
395
.25-8
P
87.8
90.6
82.7
78.6
88.9
Townsend 39
N2,Fr,CO2
Both
110
1
P,CE
100
95
88.2
90
91.6
Ostergard 11
CO2, N2
Double
344
1-5
P,E
93.7
92.5
92.9
61.2
91.6
Charles 21
Freon
Single
60
.5-3
P
***
***
***
***
53.3
Crisp 20
Freon
Single
114
***
P
***
***
***
***
100
Kaufman 40
Freon
Both
81
.6-1.5
P
100
94.4
81.3
75
86.4
Tredway 10
Freon
Both
118
0.5
C, P
86.7
92.3
69.4
***
81.4
Kaufman 12
Freon
Both
190
***
P
94.3
94.3
79
63.6
89.5
Creaseman 6
***
Single
27
.25
Cn
***
***
52
***
***
Creaseman 6
***
Double
48
.25
Cn
***
***
82
***
***
Hellberg 24
***
Double
104
2
P, C
***
***
***
***
86.5
Kaufman 41
***
Both
103
***
P
100
93.5
82.7
60
87.4
Wright 42
***
Both
152
1-3.5
P,C
92.5
88.2
75
***
85.5
Peckham 43
***
***
247
1-5
P,C
97
93.7
93.7
86.7
93.9
Richart 23
***
***
2839
10
P
98.8
99.7
99.2
***
99.2

*** Data not available or range is highly variable.

*Follow-Up Test P = Pap smear C = colposcopy Cn = conization E = endocervical curettage.