Antiretroviral (AIDS) Agents, Daily Dosage, and Major Toxicities - 2000

Page by: E.J. Mayeaux, Jr., M.D.
Louisiana State University Medical Center Shreveport, Louisiana

Nucleoside analogs

• Zidovudine, AZT (Retrovir)
• 500-600 mg po (typically 200 mg po tid) Children 3 mo- 1 2 yr:180 mg/M2 q6h, not to exceed 200 mg q6h
• Bone marrow suppression, Severe anemia, Granulocytopenia, Symptomatic myopathy, myositis (with prolonged use)
• Didanosine, ddl, (Videx)
• Two 100 mg tablets bid (> =60 kg), One 100 mg tab Plus one 25 mg tab bid (< 60 kg) Powder: 250 mg bid (> =60 kg)
• Pancreatitis, Peripheral neuropathy, Liver failure, Retinal depigmentation and change in vision (in children)
• Zalcitabine, ddc (Hivid)
• 0.75 mg po tid (0.375 mg po tid for patients <30 kg), 0.75 mg po tid
• Severe peripheral neuropathy, Pancreatitis, Esophageal ulcers, Cardiomyopathy/congestive heart failure, Anaphylactoid reaction
• Stavudine, d4T (Zerit)
• 40 mg po bid (>=60 kg), 30 mg po bid (<60 kg)
• Delayed peripheral neuropathy, Hepatotoxicity, Anemia (but decreased bone marrow toxicity in comparison to zidovudine)
• Lamivudine, 3TC (Epivir)
• 150 mg po bid (>50 kg) with AZT, 2 mg/kg po bid (<50 kg) with AZT
• Headache, insomnia, fatigue, peripheral neuropathy, myalgia

Protease inhibitors

• Saquinavir mesylate (Invirase)
• 600 mg po tid
• Generally well tolerated.
• Ritonavir (Norvir)
• 600 mg bid
• Generally well tolerated.
• Indinavir (Crixivan)
• 800 mg tid
• Generally well tolerated.