Adrenal cortical steroid inhibitors
Antacids
Antianxiety agents
Antiarrhythmics
Antibiotics
Anticonvulsants
Antidepressants
Antihistamines
Antineoplastics
Antipsychotic medications
Antithyroid drugs
Barbituates
Diuretics
Enteral nutritional supplements
Fungal medications, systemic
Gastiric acidity and peptic ulcer agents
Hypnotics
Hypolipidemics
Immunosuppressives
Oral contraceptives
Estrogen containing steroids, adrenocortical
Tuberculosis agents
Vitamins
Because a patient may be exposed to a combination of the above factors, the net effect of Coumadin on PT/INR response may be unpredictable. More frequent PT/INR monitoring is therefore advisable. Medications of unknown interaction with coumarins are best regarded with caution. When these medications are started or stopped, more frequent PT/INR monitoring is advisable.
It has been reported that concomitant administration of warfarin and ticlopidine may be associated with cholestatic hepatitis.
Effect on Other Drugs: Coumarins may also affect the action of other drugs. Hypoglycemic agents (chlorpropamide and tolbutamide) and anticonvulsants (phenytoin and phenobarbital) may accumulate in the body as a result of interference with either their metabolism or excretion.
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