Oral Hypoglycemics
Page by: E.J. Mayeaux, Jr., M.D.
Louisiana State University Medical Center Shreveport, Louisiana
Duration of Biologic half- Doses (mg) Maximum daily
Agent action (hours) life (hours) available dosage (mg) Cost($)*
Tolbutarnide 6 to 10 4 to 5 250,500 3,000 6.00 to 8.00
Acetohexamide 12 to 18 6 to 8 250,500 1,500 13.00 to 26.50
Tolazarnide 16 to 24 6 to 7 100,250,500 1,000 10.50 to 13.00
Chlorproparnide 24 to 72 30 to 36 100,250 500 4.00 to 6.50
Glipizide 16 to 24 2 to 4 5,10 40 30.00 to 30.50
Glipizide ext. 24 NA 5,10 20 30.50
(Glucotrol XL)
Glyburide 18 to 24 8 to 10 1.25,2.5,5 20 14.50 to 18.50
Micronized glyburide 16 to 24 4 to 6 1.5,3, 6 12 31.00
(Glynase)
Metformin (Glucophage) 12 1.5 to 4.5 500,850 2,550 46.00
*Estimated cost to the pharmacist based on average wholesale prices
for 100 tablets in the 1995 Red book. Prices are for generic drugs in the
lowest available dosage, except where noted.
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