Onychomychosis Treatment Regimens
Page by: E.J. Mayeaux, Jr., M.D.
Louisiana State University Medical Center Shreveport, Louisiana
Antifungal Dose/regimen Duration Activity against
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Griseofulvin 250 mg In fingernails:6-9 mo Dermatophytes*
ultramicrosize In toenails:12-18 mo
tid to qid
Ketoconaozle 200 mg/d In fingernails:6-9 mo Dermatophytes*
In toenails: 12-18 mo Some nondermatophytes
Candida
Fluconazole 150 mg In toenails: 9 mo Dermatophytes*
once each wk Candida
(increase as needed)
Itraconazole 200 mg/d In toenails: 12 wk Dermatophytes*
In fingernails: 6 wk Some nondermatophytes
or inc Scopulariopsis &
400 mg/d In toenails: 3-4 mo Aspergillus
taken first wk In fingernails: 2-3 mo Candida
of each mo
Terbinafine 250 mg/d In toenails: 12wk Demmatophytes*
In fingernails: 6wk Candida (poor)
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*Dermatophytes include Microsporum, Trichophyton, and Epidermophyton.
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