Factors
Increasing PT/INR response Listed by Drug class-2000
Adrenergic stimulants,
Alcohol abuse reduction
Analgesics
Anesthetics, inhalation
Antiarrhythmics
Antibiotics
- Aminoglycosides (oral)
- Cephalosporins, parental
- Macrolides
- Miscellaneous
- Penicillins
- Intravenous
- High dose
- Quinolones (fluoroquinolones)
- Sulfonamides, long acting
- Tetracyclines
Anticoagulants
Anticonvulsants
Antidepressants
Antimalarial agents
Antineoplastics
Antiparasitic/Antimicrobials
Antiplatelet
Drugs/effects
Antithyroid drugs
B-adrenergic blockers
Bromelains
Cholelitholytic agents
Diabetes agents, oral
Diuretics
Fungal medications
Gastrointestinal
- Ulcerative colitis agents
Gout treatment agents
Hemorrheologic agents
Hepatotoxic drugs
Hyperglycemic agents
Hypertensive emergency agents
Hypnotics
Hypolipidemics
Monoamine oxidase inhibitors
Narcotics, prolonged
NSAIDs
Psychostimulants
Pyrazolones
Salicylates
Steroids, adrenocortical
Steroids, anabolic (17-alkyl testosterone derivatives)
Thrombolytics
Thyroid drugs
Tuberculosis agents
Uricosuric agents
Vaccines
Vitamins
Because a patient may be exposed to a combination
of the above factors, the net effect of Coumadin
on PT/INR response may be unpredictable. More
frequent PT/INR monitoring is therefore
advisable. Medications of unknown interaction
with coumarins are best regarded with caution.
When these medications are started or stopped,
more frequent PT/INR monitoring is advisable. It
has been reported that concomitant administration
of warfarin and ticlopidine may be associated
with cholestatic hepatitis.
Effect on Other Drugs: Coumarins may also affect the
action of other drugs. Hypoglycemic agents (chlorpropamide and
tolbutamide) and anticonvulsants (phenytoin and phenobarbital)
may accumulate in the body as a result of interference with
either their metabolism or excretion.
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